Detection of circulating capsular polysaccharide antigen from Cryptococcus neoformans
نویسندگان
چکیده
منابع مشابه
Detection of circulating capsular polysaccharide antigen from Cryptococcus neoformans.
In their paper entitled "Comparison of the PREMIER Cryptococcal Antigen Enzyme Immunoassay and the Latex Agglutination Assay for Detection of Cryptococcal Antigens" (1), Gade et al. compare a new enzyme immunoassay (EIA) for the detection and quantification of circulating capsular polysaccharide antigen from Cryptococcus neoformans with the latex agglutination (LA) test performed with a commerc...
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cryptococcosis has become the fourth leading life-threatening opportunistic infection in patients with aids, but also occurs in non-aids patients. in view of the increasing numbers of infection during last decade in iran, use of rapid, sensitive and specific test for diagnosis of cryptococcal disease has become important than ever. we aimed to produce the reagents for latex cryptococcal antigen...
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Cryptococcus neoformans capsular polysaccharide is composed of at least two components, glucuronoxylomannan (GXM) and galactoxylomannans (GalXM). Although GXM has been extensively studied, little is known about the location of GalXM in the C. neoformans capsule, in part because there are no serological reagents specific to this antigen. To circumvent the poor immunogenicity of GalXM, this antig...
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Cryptococcus neoformans capsular glucuronoxylomannan (GXM) is shed during cryptococcosis and taken up by macrophages. The roles of the putative GXM receptors CD14, CD18, Toll-like receptor 2 (TLR2), and TLR4 in GXM clearance from serum and deposition in the liver and spleen in receptor-deficient mice were studied. While alterations in the kinetics of GXM redistribution were seen in the mutant m...
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Monoclonal antibodies that react with the capsular polysaccharide, termed glucuronoxylomannan (GXM), of Cryptococcus neoformans have potential roles in the diagnosis, monitoring of disease progress, and immunotherapy of cryptococcal GXM of all four serotypes. A molecular model of the Fab fragment of monoclonal antibody 439 was constructed from the amino acid sequence and a template antibody mol...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 1992
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.30.9.2521-.1992